From Wayne State:An off-label treatment means that the drug has not been officially approved by the FDA for a particular disease, but there is evidence and experience to support the use of that drug for the treatment of that disease.Off-label treatments are very common in medical practice and usually are the result of years of experience and research carried out by doctors and scientists. However, since these drugs have not been formally tested in phase III trials with successful results presented to the FDA, they are considered “off-label”. Nonetheless, from small scale studies, there is reasonable evidence to support their use based on their ability to reduce the frequency of relapses or slow the disease progression or both. Examples of off-label treatments for multiple sclerosis include:CyclophosphamideCellceptAzathrioprineMethotrexateIVIG (intravenous immunoglobulins)Plasmapheresis or plasma exchangeAutologous hematopoetic stem cell transplant therapylink: …
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